Protein stability during nebulization: Mind the collection step!
نویسندگان
چکیده
منابع مشابه
Aerosol delivery during continuous nebulization.
BACKGROUND AND OBJECTIVES Continuous administration of aerosolized beta 2-agonists has been suggested as an effective treatment for severe reversible airways disease. To facilitate continuous therapy and avoid a feed system for small-volume nebulizers (SVNs), a large-volume medication nebulizer (Vortran HEART) was developed. The goal of this study was to determine actual drug delivery of the HE...
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جان برتن استاد بازنشسته دانشگاه سنتاندروز، مولف کتاب جمعآوری قرآن است. این اثر در سال 1977 توسط انتشارات دانشگاه کمبریج به چاپ رسید. در نگاه اول، اثر مذکور مشتمل بر دو بخش و هر بخش دارای پنج فصل است. مولف در بخش اول به مسأله نسخ میپردازد و در مورد این که آیا قرآن سنت را نسخ کرده و یا بالعکس، به تفصیل سخن میگوید. نظرات شافعی و مخالفانش را در اینباره به طور مشروح بیان میکند. وی سه شکل ن...
15 صفحه اولA simple approach to predict the stability of phospholipid vesicles to nebulization without performing aerosolization studies.
Membrane extrusion was investigated for predicting the stability of soya phosphatidylcholine liposomes and surfactosomes (Tween 80-enriched liposomes) to nebulization. Formulations were prepared with or without cholesterol, and salbutamol sulfate (SBS) or beclometasone dipropionate (BDP) were incorporated as model hydrophilic or hydrophobic drugs respectively. Formulations were extruded through...
متن کاملPulmonary Drug Delivery Following Continuous Vibrating Mesh Nebulization and Inspiratory Synchronized Vibrating Mesh Nebulization During Noninvasive Ventilation in Healthy Volunteers.
BACKGROUND A breath-synchronized nebulization option that could potentially improve drug delivery during noninvasive positive pressure ventilation (NIPPV) is currently not available on single-limb circuit bilevel ventilators. The aim of this study was to compare urinary excretion of amikacin following aerosol delivery with a vibrating mesh nebulizer coupled to a single-limb circuit bilevel vent...
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[1] Step-pool units, common features in steep, narrow streams, are highly dynamic systems that adjust during high flows and active sediment transport conditions. Consecutive step pools in a reach form a step-pool sequence, and though these features are prevalent in nature, quantifying the stability of such systems is challenging. This study focuses on the statistical relationships between 445 s...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2020
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2020.04.006